Introducing FOXO4-DRI in a 10 mg concentration, a synthetic research peptide derived from the forkhead box O4 (FOXO4) transcription factor. Designed as a D-retro-inverso peptide, FOXO4-DRI has been studied for its ability to selectively disrupt the interaction between FOXO4 and p53, a pathway implicated in cellular senescence. This targeted activity makes it a promising tool in studies of aging, DNA damage responses, and cellular survival.

Product Details:

• Name: FOXO4-DRI 10 mg

• Catalogue Number: FX10

• Chemical Formula: C210H321N61O61S

• Molecular Weight: 5080.35 g/mol

• Purity Level: ≥99%

• Amino Acid Sequence: H-D-Arg-D-Tyr-D-Lys-D-Asp-D-Asp-D-Lys-D-Ile-D-Asn-D-Asn-D-Trp-D-Leu-D-Lys-D-Lys-D-Ser-D-Ile-D-Leu-D-Glu-D-Lys-D-Lys-D-Gly-D-Ser-D-Asp-NH₂

• Physical Form: Lyophilized Powder

Applications and Research Potential:

FOXO4-DRI has been studied in preclinical research for its potential to clear senescent cells by reactivating p53-mediated apoptosis. Experimental models suggest it may reduce markers of aging, improve tissue regeneration, and enhance resilience against oxidative stress. Its selectivity for senescent cells makes it a unique peptide for research into longevity, age-related diseases, and regenerative biology.

Handling and Storage Instructions:

FOXO4-DRI is provided as a lyophilized powder for stability. Reconstitute under sterile conditions using bacteriostatic water. Store lyophilized peptide at –20 °C in a sealed, dry environment. After reconstitution, short-term storage at 2–8 °C is recommended. All handling should follow HSE laboratory safety standards.

Production and Quality Control:

Each batch of FOXO4-DRI is manufactured using advanced solid-phase peptide synthesis (SPPS) and undergoes rigorous quality control procedures. Identity and purity are verified using HPLC and mass spectrometry to ensure reproducibility and batch-to-batch consistency.

Regulatory and Safety Notes:

FOXO4-DRI is intended for scientific research purposes only and is not suitable for human or veterinary use. Researchers must observe laboratory safety protocols and comply with applicable regulatory requirements, including MHRA guidance where relevant.

Why Choose Kensington Labs?

Kensington Labs delivers high-purity peptides developed for advanced research applications. Our FOXO4-DRI 10 mg is designed to support cutting-edge studies in senescence biology, cellular stress, and aging research, offering reliability and consistency in every vial.

Don’t forget your BACTERIOSTATIC WATER for mixing