Introducing PNC-27 in a 10 mg concentration, a synthetic research peptide developed from a segment of the human p53 protein fused with a membrane-penetrating sequence. PNC-27 has been studied for its potential to selectively interact with cancer cell membranes, particularly through binding to mitochondrial membrane proteins such as HDM-2. This unique activity has made PNC-27 of interest in preclinical studies investigating targeted cell death and tumor biology.

Product Details:

• Name: PNC-27 10 mg

• Catalogue Number: PN10

• Chemical Formula: C187H291N51O54

• Molecular Weight: 4186.65 g/mol

• Purity Level: ≥99%

• Amino Acid Sequence: H-Trp-Gly-Gly-Gly-Gly-Arg-Leu-Ile-Ser-Ser-His-His-Arg-Leu-Gly-Gly-Gly-Gly-Met-Thr-Phe-Gln-Ser-Glu-Glu-Gly-Arg-Leu-Val-Leu-Arg-Gly-Leu-NH₂

• Physical Form: Lyophilized Powder

Applications and Research Potential:

PNC-27 has been investigated in research for its potential anticancer activity, particularly in studies evaluating its ability to induce necrosis in tumor cells while sparing healthy tissues. Preclinical data suggest that PNC-27 may interact with mitochondrial and membrane proteins unique to cancer cells, making it a promising tool in oncology-focused experimental research. It remains under active investigation for its mechanisms of selective cytotoxicity.

Handling and Storage Instructions:

PNC-27 is supplied as a lyophilized powder to preserve stability. Reconstitute under sterile conditions with bacteriostatic water. Store lyophilized peptide at –20 °C in a sealed, dry environment. After reconstitution, store at 2–8 °C for short-term use. Always follow HSE laboratory safety procedures when handling peptides.

Production and Quality Control:

Each batch of PNC-27 is manufactured using solid-phase peptide synthesis (SPPS) and validated by HPLC and mass spectrometry for purity and identity. Rigorous quality control ensures batch-to-batch reproducibility, enabling reliable research outcomes.

Regulatory and Safety Notes:

PNC-27 is intended exclusively for scientific research purposes and is not suitable for human or veterinary use. Researchers must observe all laboratory safety standards and comply with applicable regulatory requirements, including MHRA guidelines.

Why Choose Kensington Labs?

Kensington Labs provides research professionals with peptides manufactured to the highest standards of quality and reproducibility. Our PNC-27 10 mg is developed for studies in cancer biology and selective cytotoxicity, ensuring researchers have access to reliable, precision-formulated materials.

Don’t forget your BACTERIOSTATIC WATER for mixing